Type I DNA Topoisomerases

DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.

Also Known As:

Topoisomerase I; DNA Topoisomerase; DNA Topoisomerases, Type I; DNA Nicking-Closing Proteins; DNA Relaxing Enzymes; DNA Type 1 Topoisomerase; DNA Untwisting Enzymes; DNA Untwisting Proteins; Type I DNA Topoisomerase; III beta, Topoisomerase; III, DNA Topoisomerase; III, Topo; III, Topoisomerase; IIIalpha, TOPO; IIIalpha, Topoisomerase; IIIbeta, Topoisomerase; Topoisomerase III, DNA; Topoisomerase, TOP3; beta, Topoisomerase III; DNA Nicking-Closing Protein; DNA Relaxing Enzyme; DNA Relaxing Protein; DNA Topoisomerase I; DNA Topoisomerase III; DNA Topoisomerase III alpha; DNA Topoisomerase III beta; DNA Untwisting Enzyme; DNA Untwisting Protein; TOP3 Topoisomerase; TOP3alpha; TOPO IIIalpha; Topo III; Topoisomerase III; Topoisomerase III beta; Topoisomerase IIIalpha; Topoisomerase IIIbeta

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Isomerases: 467
    - DNA Topoisomerases: 100
      - Type I DNA Topoisomerases: 1611
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Carrier Proteins: 13306
    - Poly-ADP-Ribose Binding Proteins
      - Type I DNA Topoisomerases: 1611
  - Nuclear Proteins: 2740
    - Poly-ADP-Ribose Binding Proteins
      - Type I DNA Topoisomerases: 1611

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Disease

Drug/Important Bio-Agent (IBA)